Melanoderma caused by a drug such as steroid are generated by excess deposition of Pigmentations such as chloasmas (or melasma), freckles, sunburn, dark skin and From these results, we may assume that melanocytes remain activated because of "a chronic, mild inflammatory condition"Īnd excessive melanin formation thus persists at the site of the spot. (melanin-producing cells) to total melanocytes is higher at the spot site It wasĪlso discovered that the number of activated melanocytes Site of the spot than at the normal site (the inflammation at the spot site isĮxtremely slight and does not manifest as redness, swelling or pain). It was found that inflammatory cells are more abundant at the When transparent DHICA solution was irradiated with UVA equivalent toĪbout 20 minutes of exposure to sunlight in the summer, pre-melanin wasĪt the sites where spots develop, excessive melanin formation constantly In the epidermis is converted to melanin upon exposure to ultraviolet A It was found that the quick skin darkening under the sun is due to theĬolorless pre-melanin DHICA (precursor of melanin) which has accumulate It has become clear that melanin, which so far has been considered to beįormed only in melanocytes, is also formed outside of melanocytes. Like due to auto-oxidation by ultraviolet rays. Tyrosine is oxidized by tyrosinase to cause biosynthesis of dopa andĭopaquinone, and the dopaquinone is converted into indolequinone or the Granule, melanosome, in the melanocyte via a complex pathway in which It is generally thought that biosynthesis of melanin occurs in a cytoplasmic Use Level: 0.5% ( cosmetics) cosmaceuticals: 2.0-3.0% It is no irritant and no sensitive to skin and is safe for use in whitening cosmetics.
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